Cheol-Heui YUN

Cheol-Heui YUN

Professor, Seoul National University, Republic of Korea

Biography

Professor Cheol-Heui YUN grew up in Gwang-ju, a southwest of Republic of Korea. He was educated at the Chonnam National University for B. Sc. and the Seoul National University for his M. Sc. in the area of Animal Nutrition. Professor Yun completed his Ph. D. at the University of Saskatchewan, Canada in the area of immune modulation and mucosal immunology. Then, he pursued his professional career at leading research institutes in different regions of the world including International Vaccine Institute (IVI, Korea), United States Department of Agriculture (USDA, USA), National Institutes of Health (NIH, USA) and Gothenburg University (Sweden) where he undertook research related to vaccinology, infection biology and adjuvanticity, and innate and cellular immune responses. Currently, he serves as editors and reviewers of a number of societies including World Journal of Immunology, Frontiers in Molecular Innate Immunity, Journal of Biomaterials and Tissue Engineering, Scientific World Journal, Journal of Microbiology, and Science Editing. He was selected and currently serves as a Deputy Editor-in-Chief of Asian-Australasian Journal of Animal Sciences. He also served as the president of Korean Dendritic Cell Academic Society. Recently, his interest has focused on and action mechanism of stress and vaccine/adjuvants against a various (mucosal) diseases in domestic animals.

SELECTED PUBLICATIONS (SINCE 2011)

1. 2-Hydroxypropyl-β-cyclodextrin induces human dendritic cell maturation via lipid raft formation and Toll-like receptor 4 activation. 2016. Frontiers in Immunology 7: 435. doi: 10.3389/fimmu.2016.00435.

2. H9N2-specific IgG and CD4+CD25+ T cells in broilers fed a diet supplemented with organic acids. 2016. Poultry Science doi: 10.3382/ps/pew382. Manuscript in press.

3. Serine-rich repeat adhesin GspB is important for Streptococcus gordonii biofilm formation. 2016. Journal of Endodontics doi: 10.1016/j.joen.2016.06.018. Manuscript in press.

4. Effects of road transportation on metabolic and immunological responses in Holstein heifers. 2016. Animal Science Journal Manuscript in press doi:10.1111/asj.12604.

5. CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells. 2016. Nature Communications 7:13373. doi: 10.1038/ncomms13373.

6. Sodium hypochlorite inactivates lipoteichoic acid of Enterococcus faecalis by deacylation. 2016. Journal of Endodontics 10(42): 1503-1508. doi: 10.1016/j.joen.2016.06.018.

7. Human salivary proteins with affinity to lipoteichoic acid of Enterococcus faecalis. 2016. Molecular Immunology 77: 52-59. doi: 10.1016/j.molimm.2016.07.013.

8. Serum bactericidal assay for evaluation of typhoid vaccine using semi-automated counting method. 2016. Microbial Pathogenesis 97: 19-26. doi: 10.1016/j.micpath.2016.05.013.

9. Stress, nutrition and immune regulation in pigs. 2016. AJAS 29(8): 1075-1082. doi: http://dx.doi.org/10.5713/ajas.16.0118.

10. Biphasic activation of extracellular signal-regulated kinase 1/2 in epidermal growth factor-stimulated SW480 colorectal cancer cells. 2016. BMB Reports 49(4): 220-225.

11. A high affinity kidney targeting by chitobionic acid-conjugated polysorbitol gene transporter alleviates unilateral ureteral obstruction in rats. 2016. Biomaterials 102: 43-57. doi: 10.1016/j.biomaterials.2016.06.013.

12. Barrier protection via Toll-like receptor 2 signaling in porcine intestinal epithelial cells damaged by deoxynivalnol. 2016. Veterinary Research 47(1): 25. doi: 10.1186/s13567-016-0309-1.

13. Serum amyloid A inhibits osteoclast differentiation to maintain macrophage function. 2016. Journal of Leukocyte Biology 99(4): 595-603. doi:10.1189/jlb.3A0415-173R.

14. Systemic administration of RANKL overcomes the bottleneck of oral vaccine delivery through microfold cells in ileum. 2016. Biomaterials 84: 286-300. doi: 10.1016/j.biomaterials.2016.01.043.

15. Dendritic cells differentiated from human umbilical cord blood-derived monocytes exhibit enhanced tolerogenic characteristics. 2015. Stem Cells and Development 24(23): 2796-2807. doi:10.1089/scd.2014.0600.

16. TLR2, but not TLR4, plays a predominant role in the immune responses to cholera vaccines. 2015. Journal of Leukocyte Biology 98(4): 661-669. doi: 10.1189/jlb.4A1014-498R.

17. Protein profiles in mucosal and systemic compartments in response to Vibrio cholerae in a mouse pulmonary infection model. 2015. Microbial Pathogenesis 86: 10-17.

18. A bacterial metabolite, compound K induces programmed necrosis in MCF-7 cells via GSK3β. 2015.

Journal of Microbiology and Biotechnology 25(7): 1170-1176.

19. Exploring the genetic signature of body size in Yucatan miniature pig. 2015. Plos One 10(4): e0121732.

20. Lipopolysaccharide of Aggregatibactor actinomycetemcomitans induces MCP-1, MIP-1α, and IP-10 via similar but distinct signaling pathways in murine macrophages. 2015. Immunobiology 220(9): 1067-1074.

21. Bacterial flagellin induces IL-6 expression in human basophils. 2015. Molecular Immunology 65(1): 168-176.

22. Differential profiles of gastrointestinal proteins interacting with peptidoglycans from Lactobacillus plantarum and Staphylococcus aureus. 2015. Molecular Immunology 65(1): 77-85.

23. Staphylococcus aureus induces IL-8 expression through its lipoproteins in the human intestinal epithelial cell Caco-2. 2015. Cytokine 75: 174-180.

24. Induction of long-term immunity against respiratory syncytial virus glycoprotein by an osmotic polymeric nanocarrier. 2014. Acta Biomaterialia 10(11): 4606-4617.

25. Major degradable polycations as carriers for DNA and siRNA. 2014. Journal of Controlled Release 193C: 74-89.

26. Stress, acute phase proteins and immune modulation in calves. 2014. Animal Production Science 54(10): 1561-1568.

27. The ribonuclease activity of SAMHD1 is required for HIV-1 restriction. 2014. Nature Medicine 20(8): 936-41.

28. Regulation of endocytosis by non-viral vectors for efficient gene activity. 2014. Journal of Biomedical Nanotechnology 10(1): 67-80.

29. Development of safe and effective RSV vaccine by modified CD4 epitope in G protein core fragment (Gcf). 2014. Plos One 9(4): e94269.

30. Survival of porcine fibroblasts enhanced by human FasL and dexamethasone-treated human dendritic cells in vitro. 2014. Transplant Immunology 30(2-3): 99-106.

31. Anti-bacterial and anti-toxic immunity induced by a killed whole-cell-cholera toxin B subunit chloera vaccine is essential for protection against lethal bacterial infection in mouse pulmonary cholera model. 2013. Mucosal Immunology 6(4): 826-837.

32. Lipoproteins are an important bacterial component responsible for bone destruction through the induction of osteoclast differentiation and activation. 2013. Journal of Bone and Mineral Research

28(11): 2381-2391.

33. Muramyl dipeptide potentiates the ability of staphylococcal lipoteichoic acid to induce cyclooxygenase-2 expression in murine macrophages. 2014. Microbes and Infection 16(2): 153-160.

34. The effect of RNAi silencing of p62 using an osmotic polysorbitol transporter on autophagy and tumorigenesis in lungs of K-rasLA1 mice. 2014. Biomaterials 35(5): 1584-1596.

35. Regulation of endocytosis by non-viral vectors for efficient gene activity. 2014. Journal of Biomedical Nanotechnology 10(1): 67-80.

36. Functional characteristics of porcine peripheral T cells stimulated with IL-2 or IL-12 and PMA. 2014.

Research in Veterinary Science 96(1): 54-61.

37. Curcumin inhibits CD4+ T cell activation, but augments CD69 expression and TGF-b1-mediated

generation of regulatory T cells at late phase. 2013. Plos One 8(4): e62300.

38. Lipoteichoic acid of Enterococcus faecalis induces the expression of chemokines via TLR2 and PAFR signaling pathways. 2013. Journal of Leukocyte Biology 94(6):1275-84.

39. Orientia tsutsugamushi infection induces CD4+ T cell activation via human dendritic cell activity. 2013. Journal of Microbiology and Biotechnology 23(8): 1159-1166.

40. Anti-bacterial and anti-toxic immunity induced by a killed whole cell-cholera toxin B subunit cholera vaccine is essential for protection against lethal bacterial infection in mouse pulmonary cholera model. 2013. Mucosal Immunology 6(4): 826-37. doi:10.1038/mi.2012.121.

41. Induction of B cell-activating factor (BAFF) expression by interferon-gamma in the human intestinal epithelial cells. 2013. Journal of Leukocyte Biology 93(3): 363-368.

42. LTA suppresses effector T cells induced by Staphylococcus aureus-pulsed dendritic cells. 2013.

Journal of Microbiology and Biotechnology 23(7): 1023-1030.

43. Sublingual administration of bacteria-expressed influenza virus hemagglutinin 1 (HA1) induces protection against infection with 2009 pandemic H1N1 influenza virus. 2013. Journal of Microbiology 51(1): 130-135.

44. Alpha-amylase is a human salivary protein with affinity to lipopolysaccharide of Aggregatibacter actinomycetemcomitans. 2013. Molecular Oral Microbiology 28 (2): 142–153.

45. The role of osmotic polysorbitol-based transporter in RNAi silencing via caveolae-mediated endocytosis and COX-2 expression. 2012. Biomaterials 33(34): 8868-8880.

46. Design and application of chitosan microspheres as oral and nasal vaccine carriers: an Updated Review.

2012. International Journal of Nanomedicine 7: 6077-6093.

47. Sublingual immunization with recombinant adenovirus encoding SARS-CoV spike protein induces systemic and mucosal immunity without redirection of the virus to the brain. 2012. Virology Journal 9(1): 215.

48. The effects of fermented soybean meal on immunophysiological and stress-related parameters in Holstein calves after weaning. 2012. Journal of Dairy Science 95(9): 5203-5212.

49. Gene expression profiles of human peripheral blood mononuclear cells induced by Staphylococcus aureus lipoteichoic acid. 2012. International Immunopharmacology 13(4): 454-460.

50. Guidelines for the use and interpretation of assays for monitoring autophagy. 2012. Autophagy (4): 445-544.

51. IFN-γ renders human intestinal epithelial cells responsive to lipopolysaccharide of Vibrio cholerae by down-regulation of DMBT1. 2012. Comparative Immunology, Microbiology & Infectious Diseases

35(4): 345-354.

52. KLF10, transforming growth factor-β-inducible early gene 1, acts as a tumor suppressor. 2012.

Biochemical and Biophysical Research Communications 419(2): 388-394.

53. Enhanced efficacy of therapeutic cancer vaccines produced by co-treatment with Mycobacterium tuberculosis heparin-binding hemagglutinin, a novel TLR4 agonist. 2011. Cancer Research 71(8): 2858-2870.

54. Accelerated gene transfer through a polysorbitol-base transporter mechanism. 2011. Biomaterials

32(36): 9908-9924.

55. Sublingual immunization with M2-based vaccine induces broad protective immunity against influenza. 2011. Plos One 6(11): e27953.

56. Inhibition of xenograft tumor growth in mice by gold nanoparticle-assisted delivery of short hairpin RNAs against Mcl-1L. 2011. Journal of Biotechnology 156(2): 89-94.

57. Mucoadhesive alginate/poly (L-lysine)/thiolated alginate microcapsules for oral delivery of

Lactobacillus salivarius 29. 2011. Journal of Nanoscience and Nanotechnology 11(8): 7091-7095.

58. Identification of Porphyromonas gingivalis lipopolysaccharide-binding proteins in human saliva. 2011. Molecular Immunology 48(15-16): 2207-2213.

59. Lipoteichoic acid from Lactobacillus plantarum induces nitric oxide production in the presence of interferon-γ in murine macrophages. 2011. Molecular Immunology 48(15-16): 2170-2177.

60. Interactions of dendritic cells with cancer cells and modulation of surface molecules affect functional properties of CD8+ T cells. 2011. Molecular Immunology 48(15-16): 1744-1752.

61. Impaired IFN-g production after stimulation with bacterial components by natural killer cells from gastric cancer patients. 2011. Experimental Cell Research 317(6): 849-858.

62. Effects of hydrolyzed yeast supplementation in calf starter on immune responses to vaccine challenge in neonatal calves. 2011. Animal 5(6): 953-960.

63. The stress of weaning influences serum levels of acute-phase proteins, iron-binding proteins, inflammatory cytokines, cortisol, and leukocyte subsets in Holstein calves. 2011. Journal of Veterinary Science 12(2): 151-157.

64. Induction of intercellular adhesion molecular-1 by water-soluble components of Hericium erinaceum in human monocytes. 2011. Journal of Ethnopharmacology 133(2): 874-880.